From pandas to pans: a nosographic entity in evolution throughout a descriptive analysis of a cohort of 103 italian children and adolescents
نویسندگان
چکیده
Introduction The acronym PANDAS reveals a pediatric autoimmune neuropsychiatric disorder associated with Streptococcus pyogenes infection. This disorder is defined by: (a) the presence of obsessive-compulsive disorder (OCD) or tics; (b) abrupt onset and remitting/relapsing course; (c) prepuberal onset of all symptoms; (d) temporal association with a group A b-hemolytic S. pyogenes infection; (e) association with neurologic disorders (hyperactivity, choreiform movements, etc). In addition to PANDAS, another pediatric neropsychiatric syndrome with an abrupt onset is now recognized. This disorder is called PANS and is characterized by different neuropsychiatric manifestations, which seem to be temporally associated with infectious agents different from S. pyogenes or with other environmental triggers.
منابع مشابه
Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part III—Treatment and Prevention of Infections
Objectives: Pediatric acute-onset neuropsychiatric syndrome (PANS) and its subset, pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS), are emerging autoimmune encephalopathies of childhood. Management guidelines are needed. This article, from the PANS PANDAS Consortium, presents a consensus management guideline for the infection components. Accompany...
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OBJECTIVE This article outlines the consensus guidelines for symptomatic treatment for children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Syndrome Associated with Streptococcal Infection (PANDAS). METHODS Extant literature on behavioral, psychotherapeutic, and psychopharmacologic treatments for PANS and PANDAS was reviewed. Members o...
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PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) syndrome is a disorder that presents itself before adolescence with an abrupt onset of obsessive-compulsive disorder symptoms and/or tics. This disorder is related to Group A streptococcal (GAS) infection with neurological findings, such as motor hyperactivity and choreiform movements. The progress...
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Despite continued debates about the role of Group A streptococcal infections in the etiopathogenesis of PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections), experts on both sides of the controversy agree that a subgroup of children with obsessive-compulsive disorder (OCD) have an unusually abrupt onset of symptoms, accompanied by a variety of compar...
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Methods Descriptive analysis of a cohort of Italian patients with PANDAS.Between may 2009 may 2013 we observed 65 pts (50 M, 15 F, mean age: 100.8 ± 32,9 months) with OCD and/or tics starting before puberty, associated with a previous GAS infection. Demographic and familiar data, routine and specific laboratory data: thyroid function, autoimmunity tests (ANA, anti-dsDNA, antiENA, anti-cardiolip...
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